Synergic effect between TRAIL gene and curcumin in magnetic chitosan nanoparticles on cancer cells apoptosis enhanced by laser photoactivation
نویسندگان
چکیده
Abstract The Apoptosis is an intensely studied mechanism for cancer therapy. Various genes, drugs, and molecules have been combined to potentiate the apoptotic effect against tumor cells. Magnetic nanocomplexes with biopolymers proposed as nanocarriers delivery of active improve apoptosis induction. To these purpose were formulated magnetic nanoparticles curcumin coated chitosan (MNPs-CHI-TPP-CUR) pCEM-TRAIL plasmid (MNPs-CHI-TPP-TRAIL) use alone or in combination induce B16F10 cells because capable overexpressing receptors TRAIL required Also, (CUR) has used a photosensitizer photodynamic therapy (PDT). In this work, it was produced characterized gene. Both types ~ 200 nm size. results showed that induced significant increase cellular death within 48 h compared each nanocomplex individually, demonstrating synergic effect. This first description interaction between gene drug determined potentiated when treated exposed laser photoactivation wavelengths 405 532 15 min. Graphical abstract
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ژورنال
عنوان ژورنال: Journal of Nanoparticle Research
سال: 2022
ISSN: ['1572-896X', '1388-0764']
DOI: https://doi.org/10.1007/s11051-022-05544-x